Research Patents
PATENTS
  1. ​Smart Stent-a real time piezoresistive Based Displacement Monitoring concept-2020

  2. Power air purifying respirator-2021

  3. Murtaza Najabat Ali, Mechanical Ventilator for ICU and Non-ICU Applications, 2020                                                                                                            The present invention is a ventilator system designed to meet the requirements of patients in acute respiratory distress. The servo-based adjustable proportional valve-based ventilator system discussed supports various ventilation modes such as continuous mandatory ventilation, assist control ventilation and spontaneous breathing supports that may be controlled by adjustable valves and machine parameters that can be monitored on the graphical user interface that specifically supports this device and its multiple features.

  4. Murtaza Najabat Ali, Hafsa Inam, Hybrid Braid Configuration of Diagnostic Angiographic Catheter                                                                                  To provide a catheter which has a hybrid reinforcement structure by braiding and coiling, places a low burden on a blood vessel, has smooth reachability, and has sufficient pressing property as rigidity on the proximal side is enhanced. It is a composite catheter and is used for flushing the media to the targeted site in a lumen system of a patient's body. The hybrid-braided tube discussed here having multiple braiding patterns to ensure the flexibility and improve the structural stability of catheter tube with kink resistant and better torque transfer throughout the tube. There are different types of hybrid braid configurations with various inner lumens and out jackets materials as well as the modified surface for drug coating and hydrophilic coating adherence onto the catheter surface is introduced according to their intended use. Various shapes and braids are customised to fulfil specific requirement in medical applications

  5. Murtaza Najabat Ali (2013), “AUXETIC STRUCTURES AND THEIR APPLICATIONS IN NON-VASCULAR PATHOLOGIES”, 104/2013                Auxetic structure, including three-dimensional Auxetic films and Stents, are disclosed and applied to maintain the luminal patency of the diseased in vivo tubular pathways and to support the tubular structures, such as oesophagus, other gastrointestinal tubes, bile ducts and pulmonary passageways. One such structure constructed in accordance with this invention comprises of a plurality of unit cells. Each unit cell comprises of four angulated squares connected in a way to create a hollow rhombus (diamond-shaped) space between them. One such unit cell comprises of eight vertices; where four vertices A, B, C and D are the vertical vertices which connect to the neighbouring unit cells. The other four vertices a, b, c and d are the horizontal vertices which link to the adjacent unit cells of the same orientation. The unit cells are connected in rows and columns, and the expansion of Auxetic structure leads to the expansion of the structure in both axes. The Auxetic structure configurations invented can also be used, with similar dimensions or significantly different dimensions, for other applications. The three-dimensional Auxetic film used to manufacture seamed Auxetic stents, whereas seamless fabrication of the Auxetic stent is also disclosed.

  6. Murtaza Najabat Ali, Faisal Amin, (2014) “ANISOTROPIC STENT DEVICE FOR THE TREATMENT OF CORONARY HEART DISEASE”, 26/2014                                                                                                                                                                                                                                                                                              This invention relates to the stent device for the coronary artery of the human heart, which is used to treat coronary artery disease and prevent localised blood flow constriction in obstructed coronary artery. The present invention demonstrates negative Poisson’s ratio and comprises of a new Auxetic structure, which makes the mechanical properties of the stent anisotropic. Therefore, a good mechanical adhesion between stent and arterial wall can be achieved owing to the anisotropic nature of the Auxetic stent and arterial wall. This design of coronary stent has the capability to retain the coronary artery patency after it is expanded in both radial and longitudinal directions. The Auxetic structure stent of present invention constructed with the plurality of unit cells interconnected with horizontal and vertical edges to form hinges and struts of the coronary stent. The structure of single unit cell consists of hollow diamond along with four angulated squircles. The horizontal edges of the unit cells joined the unit cells in the horizontal direction whereas vertical edges joined the unit cells in the vertical direction, thus forming the array of unit cells in the radial and horizontal directions. A conventional fabrication technique such as CNC precise laser cutting technique and surface treatment methods were used to develop the present invention of coronary stent. Moreover, this invention of Auxetic coronary stent shows no foreshortening and elastic recoil once it is deployed and plastically deformed.

  7. Murtaza Najabat Ali, Zainab Munib (2014), “COUNTER-INTUITIVE AUXETIC INTRAMEDULLARY BONE STENT AND A METHOD FOR TREATING LONG BONE FRACTURES”, 77/2014                                                                                                                                                                                                              The present invention provides an Auxetic structure, including an Auxetic film and tubular stent for long bone fractures that is implanted into the medullary canal, where it spans the fracture site, providing stability and compression. The device is constructed from an Auxetic material and comprises of a plurality of unitcells. Each unitcell comprises of six triangles connected in such a manner that creates a hollow star (three-pointed) shape at the centre of each unitcell. The stars are connected through their vertices via flexible hinges creating a structure of rigid rotating triangles. An array/pattern is created by repeating the connection of unitcells in both vertical and horizontal directions. The Auxetic nature (materials with negative value of Poisson’s ratio) of the stent allows the expansion of the structure in both radial and longitudinal directions. The Auxetic system can be made from similar dimensions or a connection of different sized triangles to achieve a wide range of Poisson’s ratio values. The three-dimensional Auxetic film used to manufacture seamed Auxetic stents, whereas seamless fabrication of the Auxetic stent is also disclosed.

  8. Murtaza Najabat Ali, Mariam Mir (2014), “Intelligent Bandage with Drug Dispensation and Adjustable Porosity System for Topical Wounds”, 291/2014                                                                                                                                                                                                                                                                                                          A bandage assembly for simultaneous wound healing and controlled drug delivery application, comprising three different components is presented here. The bandage assembly is made for topical wounds and is composed of an Auxetic polymeric film, a drug reservoir, and a mechanism which will control the pore size of the Auxetic film and hence the transdermal delivery of drug through the wound. The three components of the bandage assembly are arranged in laminar fashion, one atop the other, conjugated at the ends. The Auxetic polymer film is composed of rotating squares geometry and has a negative Poisson’s ratio. Linear expansion of the controlling mechanism will also cause expansion of the attached polymeric film in both vertical and horizontal directions. The structure that controls film expansion operates through a scissor-like mechanism. The length of the mechanism increases in linear (vertical) direction if contractile force is applied at one end (horizontally) of the structure, that is perpendicular to the direction of linear extension. Thus the degree of linear extension in one direction influences expansion of the film beneath as well as the change in size of the pores of the Auxetic film, and hence the rate at which drug is delivered to the site of the wound.

  9. Murtaza Najabat Ali, Seemab Mehmood,(2014), “A Novel Skeletal Plate Fixation System for Tubular and Flat Bones Fractures”, 396/2014                       The invention is related to the skeletal plate systems for tubular and flat bones, which aligns and upholds bone portions of the fractured bone in a selected spatial assembly. The present invention relates to negative Poisson’s ratio and provides a fracture fixation device of Auxetic nature which aligns and sustains the bone fragments in order to impart appropriate assembly to accomplish bone healing. The device described herein provides better alignment of bone portions and helps promote healing due to its Auxetic nature. Skeletal plate fixation system comprises an Auxetic plate and screws designed to stabilize bone upon attachment. The Auxetic structure of the present invention aims to restore the fractured segments back to their original anatomical location through micro-motion. The Auxetic structure allows for efficient fixation because its negative Poisson’s ratio allows for micro-movement, thereby offering a stable fixation with relative stability rather than absolute stability and promoting bone healing without causing any damage to blood supply or osteo-necrosis.

  10. Mariam Mir, Murtaza Najabat Ali (2014), “A Multifunctional Device that Promotes Wound Healing through Drug Delivery and Exudate Removal”, 711/2014                                                                                                                                                                                                                                                                                                          A wound healing device that acts through controlled drug delivery and exudate uptake is presented here. The wound healing device is designed for use on topical wounds and primarily comprises of a laminate arrangement of components that function together to aid wound healing. Drug delivery to the wound is controlled through an internal assembly of an auxetic polymeric membrane connected to a lead screw mechanism that is electronically modulated. Since the extension of the auxetic membrane is electronically controlled, the opening of the pores in the membrane can limit the elution of drug through the film and hence the amount of drug that reaches the wound bed. The skin contacting polymeric surface of the device has been designed with several features that aid in exudate uptake in response to negative pressure applied to the polymeric membrane surface. This device therefore, is meant for long term use, as the need for multiple dressing changes is circumvented because of the dual features of controlled drug delivery and exudate removal through the treatment regimen.

  11. Murtaza Najabat Ali, M. Kashan Siddiqui (2017), “Industrial Automation Solution for Quality Testing of Suturing Needle Holder”, 428/2017                  A needle holder, also known as needle driver, is a surgical instrument, similar to a haemostat, used by doctors and surgeons to hold a suturing needle for closing wounds during suturing and surgical procedures. The parts of a simple needle holder are the jaws, the joint and the handles. Most needle holders also have a clamp mechanism that locks the needle in place, allowing the user to manoeuvre the needle through various tissues. The device is manufactured through conventional processes and machining techniques. But through last few stages, the dimensional accuracy and functional quality is given great consideration. A decisive quality test is the ability of the Needle Holder to effectively hold suturing thread when given tension, normally referred to as Thread Tension Test. This specific test is conventionally performed by hand, and therefore lot to lot inconsistencies in product dimensions and functionality are imminent. This invention is the design of an industrial automation system which not only speeds up the Thread Tension Test, but also ensures consistent test parameters for pass/fail labelling of Needle Holders. The design of this invention is based on principles of mechanical engineering, electronic circuits and components, control systems and computer programming.

  12. Murtaza Najabat Ali, Tehreem Jamil (2018),“Ligament augmentation stent technology for augmenting Anterior cruciate ligament healing through primary repair”, 689/2018                                                                                                                                                                                                                                                                    The design of a ligament augmentation device is disclosed, this design implemented in ligament repair device can be used to augment the healing process of anterior cruciate ligament through primary repair. This device will not only be bioactive to help in the healing process of the ligament but also withstand the forces that act on the ligament during the motion of the knee. The design of the device is in a seamless tubular configuration and its geometry consists of multiple slit that are in inter-articular region and holes at both the ends of the device. Gates are located inside the tubular device, they seal off the ends of the device located in the bony tunnels from the part of the device that is to be fixed inside the knee joint. The feature of gates has been incorporated into the design of the device to allow the device to be fixed with bone cement. This document also discloses the fabrication methods used to produce ligament augmentation stent technology, LAST, a seamless tubular ligament augmentation device.

  13. Murtaza Najabat Ali, Mariam Mir (2018) “Smart Wounf Management System for Controlled Drug Delivery and Ph Monitoring”, 681/2018

  14. Murtaza Najabat Ali, Faiza Bukhari, Hafsah Akhtar (2018), “A Novel Deployment Device for Stents having Negative Poisson’s Ratio”, 690/2018           An expansion device for deployment of auxetic stents, comprising of multiple parts is presented here. The deployment device is designed specifically for expansion of auxetic stents and is composed of circular rods and spokes. The length of spokes and rods will control the extent of elongation both radially and longitudinally. All the parts of the deployment device are arranged in order to obtain umbrella shaped geometry connected end to end. The Auxetic polymeric stent is composed of rotating square geometry having negative Poisson’s ratio. The device is actuated through hydraulic pressure applied by inflation device. The device and the stent expansion operates through an umbrella like mechanism. The length of auxetic stent increases when external pressure is applied. The spokes are expanded in response to pressure thus expanding the stent radially. The degree of linear expansion in one direction influences expansion of auxetic stent in other direction as well. As the device exerts pressure longitudinally, the force is applied on more unit cells/hinges which results in overall expansion of auxetic stent.

PUBLISHED PAPERS
  1. Ghafoor, B., Ali, M. N., & Riaz, Z. (2020). Synthesis and Appraisal of Natural Drug-Polymer-Based Matrices Relevant to the Application of Drug-Eluting Coronary Stent Coatings. Cardiology Research and Practice, 2020, 1–11. doi:10.1155/2020/4073091

  2. Riaz, Z., Ali, M. N., Qureshi, Z., & Mohsin, M. (2020). In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research, 2020, 1–9. doi:10.1155/2020/7357482

  3. Murtaza Najabat Ali, Ihtesham U Rehman, (2011), “An Auxetic structure configured as oesophageal stent with potential to be used for palliative treatment of oesophageal cancer; development and in vitro mechanical analysis”, Journal of Materials Science: Materials in Medicine; Vol. 22 Issue 11, p2573

  4. Faisal Amin, Murtaza Najabat Ali, Muhammad AsimMinhas (2013), "An Evolutionary Appraisal of the Efficacy of Coronary Artery Stents relevant to the Treatment of Coronary Heart Diseases", International Journal of Biomedical and Advance Research, Vol.4 Issue 11

  5. M.N.Ali, James J.C. Busfield, Ihtesham U. Rehman (2013), “Auxetic oesophageal stents: structure and mechanical properties, Journal of Material Science: Materials in Medicine, Volume 25, Issue 2, pp 527-553.

  6. M.N.Ali, Faisal Amin (2014), “Smart stent: A new concept for the treatment of central airway obstructions", NUST Journal of Engineering Sciences, Vol. 5 No.1, pp. 27-34

  7. SeemabMehmood, Umar Ansari, Murtaza Najabat Ali (2014), “Internal fixation: An evolutionary appraisal of methods used for long bone fractures”, International Journal of Biomedical and Advance Research, Vol. 5 issue 3.

  8. Zainab Munib, Umar Ansari, Murtaza Najabat Ali, (2014),"A paradigm shift of the conventional intramedullary devices to new biological osteosynthetic devices: Bone stents ", International Journal of Biomedical and Advance Research, Vol.5 Issue 3.

  9. Rabeil Sakina, Murtaza Najabat Ali (2014), "An appraisal of the efficacy and effectiveness of nanoscaffolds developed by different techniques for tissue engineering and orthopedic applications: Electrospinning A Paradigm shift", Advances in Polymer Technology.

  10. Murtaza Najabat Ali, Faisal Amin, Umar Ansari, Mariam Mir, Muhammad Asim Minhas (2014), “Anisotropic Coronary Stent Device: Fabrication and Structural Analysis”,WIT Transactions on Engineering Sciences, Vol.99.

  11. Faisal Amin, Murtaza Najabat Ali, Umar Ansari, Mariam Mir, Muhammad Asim Minhas and WakeelShahid, (2014),“Auxetic Coronary Stent Endoprosthesis: Fabrication and Structural Analysis”, Journal of Applied Biomaterials & Functional Materials

  12. Tehreem Jamil, Mariam Mir, Faisal Amin, Umar Ansari, Murtaza Najabat Ali, Nauman ul Haq (2014), “Fabrication and mechanical testing of synthetic cervical anterior longitudinal ligament”, POLIMERY Journal.

  13. Murtaza Najabat Ali, Ihtesham U. Rehman (2014),"Auxetic polyurethane stents and stent-grafts for the palliative treatment of squamous cell carcinomas of the proximal and mid oesophagus: A NOVEL FABRICATION ROUTE", Journal of Manufacturing Systems

  14. Murtaza Najabat Ali,Faisal Amin, Mariam Mir, Umar Ansari (2014), “Emerging Approach for Treating Complications Associated with Pertrochanteric Fractures: A Review”, Minerva Ortopedica E Traumatologica, 66 (2).

  15. Mariam Mir, Murtaza Najabat Ali, Umar Ansari, Javaria Sami, , (2014), “Review of Mechanics and Applications of Auxetic Structures” Advances in Materials Science and Engineering

  16. Munneza Ata Khan, Umar Ansari, Murtaza Najabat Ali, (2015), “Real-time wound management through integrated pH sensors: A Review", Sensor Review

  17. Zainab Munib, Murtaza Najabat Ali, Umar Ansari, Mariam Mir (2015), “Auxetic Polymeric Bone Stent for Tubular Fractures: DESIGN, FABRICATION AND STRUCTURAL ANALYSIS”, Polymer-Plastics Technology and Engineering

  18. Seemab Mehmood, Murtaza Najabat Ali, Umar Ansari, Mariam Mir, Munezza Ata Khan (2015), "Auxetic Polymeric Bone Plate As Internal Fixator For Long Bone Fractures: Design, Fabrication And Structural Analysis", TECHNOLOGY AND HEALTH CARE

  19. Mariam Mir, Murtaza Najabat Ali, Umar Ansari, Javaria Sami, (2015), “Structure and Motility of the Esophagus from a Mechanical Perspective” ESOPHAGUS-TOKYO

  20. Mariam Mir, Umar Ansari, Murtaza Najabat Ali, (2014),"A Macro-Scale Model of a Tunable Drug Dispensation Device for Enhanced Wound Healing", Journal of Applied Biomaterials & Functional Materials

  21. Bakhtawar Ghafoor, Murtaza Najabat Ali, Umar Ansari, Muhammad Faraz Bhatti, Mariam Mir, Hafsah Akhtar, Fatima Darakhshan, (2016), “New Bio functional loading of Natural Anti-microbial agent in biodegradable Polymeric films for Biomedical Applications", International Journal of Biomaterials

  22. Murtaza Najabat Ali, Umar Ansari, Javaria Sami, Faisal Qayyum (2016), “To develop a biocompatible and biodegradable polymer-metal composite with good;mechanical and drug release properties”, Journal of Materials Sciences and Engineering, Vol.5, issue 5

  23. Faiza Bukhari, Murtaza Najabat Ali, Umar Ansari, Hafsah Akhtar, Muhammad Sarim, Muhammad Umer (2016) “A biaxial strain based expansion mechanism for Auxetic stents deployment”, Journal of Applied Biomaterials & Functional Materials (JABFM)

  24. Tehreem Jamil, Umar Ansari, Murtaza Najabat Ali (2016), “A Review on Biomechanical and Treatment Aspects Associated with Anterior Cruciate ligament”, Innovation and Research in Biomedical Engineering (IRBM)

  25. Mariam Mir, Umar Ansari, Murtaza Najabat Ali, Muhammad Hassan ul Iftikhar, Faisal Qayyum (2016), “Electromechanically Actuated Multifunctional Wireless Auxetic Device for Wound Management”, IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE-JTEHM

  26. Mariam Mir, Murtaza N Ali, Afifa Barakullah, Aishah Gulzar, Munam Arshad, Shizza Fatima, Maliha Asad, (2017),“POLYMERIC BIOMATERIALS FOR WOUND HEALING-A REVIEW", Progress in Biomaterials

  27. Mariam Mir, Murtaza Najabat Ali, Patrick. J. Smith, Ambar Zahoor, Umar Ansari, Faisal Qayyum, Sabtain Abbas, (2017), “AQUA-GEL pH SENSOR: Intelligent Engineering and Evaluation of pH Sensor based on Multi-Factorial Testing Regimes”, SENSOR REVIEW

  28. Mariam Mir, Murtaza N. Ali, Amber Zahoor, Patrick Smith (2018), “Comparison of Sensing Behaviour of two hydrogel based polymeric materials in the physiological range”, Biomedical Physics & Engineering Express

  29. Muhammad Umer, Murtaza Najabat Ali, Aamir Mubashar, Mariam Mir (2018), “Computational Modeling of the Balloon Expandable Stent Deployment in Coronary Artery Using Finite Element Method”, Research Reports in Clinical Cardiology

  30. Bakhtawar Ghafoor, Amna Aleem, Murtaza Najabat Ali, Mariam Mir, (2018), “Review of the Fabrication Techniques and Applications of Polymeric Electrospun nanofibers for drug delivery systems”, Journal of Drug Delivery Science and TechnologyBook Chapter

  31. Murtaza Najabat Ali, Umar Ansari , Mariam Mir, Fatima Darakhshan, Bakhtawar Ghafoor, Misha Mazhar (2015), “HYDROGELS: Recent Advances and Applications”, Handbook Polymer Gels, published by Springer

CONFERENCE PAPERS
  1. Murtaza Najabat Ali, Umar Ansari, Javaria Sami, Faisal Qayyum (2016), “To develop a biocompatible and biodegradable polymer-metal composite with good; mechanical and drug release properties”, 5th World Congress on Materials Science and Engineering, Alicante Spain

  2. Tehreem Jamil, Mariam Mir, Faisal Amin, Umar Ansari, Murtaza Najabat Ali, NaumanulHaq (2014), “Fabrication and mechanical testing of synthetic cervical anterior longitudinal ligament“ 2014 Global Conference on Polymer and Composite Materials (PCM2014)

  3. Murtaza Najabat Ali, Faisal Amin, Umar Ansari, Muhammad AsimMinhas (2014), “Anisotropic Coronary Stent Device: Fabrication and Structural Analysis”, International Conference on Future Mechanical Engineering and Materials Engineering (MEME 2014)

  4. M.N.Ali (2013), “ An Auxetic stent relevant for the treatment of oesophageal cancer,” International Science and Technology Conference (ISTEC)

  5. Murtaza Najabat Ali (2008), “An Overview of Auxetic Materials and their Clinical Relevance” One day symposium on Biomedical Materials at CIIT (IRCBM)

  6. Murtaza Najabat Ali (2009) “Smart Auxetic Material self-expanding Esophageal Stent-graft, relevant to the palliation of Oesophageal Cancer”, 6th International Bhurban Conference on Applied Sciences and Technology (IBCAST)

  7. Mariam Mir, Murtaza Najabat Ali, Ayesha Gulzar, Afifa Barakullah, Munam Arshad, Bakhtawar Ghafoor, Hafsa Inam (2018), “Design and fabrication of a hydrogel based pH sensor array for physiological applications”, 19th World Congress on Material Sciences and Engineering at Barcelona, Spain

  8. Bakhtawar Ghafoor, Aisha Tahir, Murtaza Najabat Ali, Mariam Mir, Hassan Ali and Hafsa Inam (2018), “Synthetization and characterization of natural biocompatible composite having sustained drug release mechanism for topical and subcutaneous applications”, 19th World Congress on Material Sciences and Engineering at Barcelona, Spain

  9. Hafsa Inam, Murtaza Najabat Ali, Mariam Mir, Ammad Ahmed, Manal Fatima and Bakhtawar Ghafoor (2018), “Designing and fabrication of anisotropic stent for the treatment of coronary heart disease”, 19th World Congress on Material Sciences and Engineering at Barcelona, Spain